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KMID : 0385219990090010018
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Korean Journal of Gerontology
1999 Volume.9 No. 1 p.18 ~ p.22
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Inhibitory Effect of Histamine Release from Murine Peritoneal Mast Cells by Intraperitoneal Caffeine Administration
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Chung Jong-Gab
Sim Kyung-Sik
Kim Hyung-Ryong
Kim Hyung-Min
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Abstract
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We have investigated the effects of caffeine on anaphylaxis in murine model. An IgE-dependent local anaphylaxis was generated by sensitizing the skin with anti-dinitrophenyl (DNP) IgE followed 48 hr later with an injection of antigen. Caffeine (0.1 mg/kg) inhibited to 56.4U0.4% passive cutaneous anaphylaxis activated by anti-DNP IgE. Systemic anaphylaxis by compound 48/80 injection was monitored for 1 hr. Caffeine inhibited compound 48/80-induced anaphylatic shock to 40% with a dose of 1 mg/kg. Caffeine (5 to 20 mM) significantly inhibited histamine release from rat peritoneal mast cells (RPMCs) activated by anti-DNP IgE or compound 48/80. Especially, caffein (20 mM) inhibited by 96.7U0.5% histamine release activated by compound 48/80. Our studies provide evidence that caffeine will be beneficial in the treatment of anaphylaxis.
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KEYWORD
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Caffeine, Anaphylaxis, Histamine, Rat peritoneal mast cells
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